Health risk assessment of the concentration of trace elements in cosmetic products in Sanandaj, Iran

Document Type : Original Article


1 Assistant Professors, Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran

2 Professors, Environmental Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran

3 Professors, Department of Medical Entomology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

4 Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran


This study was conducted to determine the concentrations of Ag, Cd, Cr, Cu, Fe, Ni, Pb, and Zn in the commonly used cosmetic products such as eyeshadows, eyeliners, and skin whitening creams in markets of Sanandaj city, Iran in 2014. In this study, 60 samples comprising of three different types of eyeshadows, eyeliners, and skin whitening creams were purchased randomly from different cosmetic shops in Sanandaj city. The cosmetic product samples were digested using wet digestion method. Trace elements were assayed using an ICP-OES. According to the results, Ag and Fe were the trace elements with the lowest and highest concentration in the three brands, respectively. Moreover, the results indicated that eyeshadow contains the highest (except Ag and Cd) concentrations of trace elements. On the other hand, the levels of HQ for trace elements in the cosmetic products decreased in the following order: Zn > Cr > Cd > Fe > Cu > Ag > Ni > Pb. The trace element concentrations in the three brands of cosmetic products in our research were lower than the international standards and similar to those reported from researchers in different parts of Iran, but according to the accumulation and toxicity of these trace elements in the human body, they require periodic monitoring. 


  1. Karimi G, Ziarati P. Heavy metal contamination of popular nail polishes in Iran. Iranian J Toxicol 2015; 9(29):1290-1295.
  2. Nowrouzi M, Mansouri B, Hamidian AH, Ebrahimi T, Kardoni F. Comparison of the levels of metals in feathers of three bird species from southern Iran. Bull EnvironContam Toxicol 2012; 89(5): 1082-1086.
  3. Hoshyari E, Pourkhabbaz A, Mansouri B. Contaminations of metal in tissues of Siberian gull (Larus heuglini): gender, age, and tissue differences. Bull EnvironContam Toxicol 2012; 89(1):102–106
  4. Smith DR, Flegal AR. Lead in the Biosphere; Recent Trends. Ambio 1995; 24(1): 21 – 23.
  5. Duruibe JO, Ogwuegbu MOC, Egwurugwu JN. Heavy metal pollution and human biotoxic effects. Int J Physic Sci 2007; 2(5): 112-118.
  6. Rajaei G, Mansouri B, Jahantigh H, Hamidian AH. Heavy metal concentrations in the water of the Chah nimeh reservoirs from Zabol, Iran. Bull EnvironContam Toxicol 2012; 89(3):495–500
  7. Nourmoradi H, Foroghi M, Farhadkhani M, Vahid Dastjerdi M. Assessment of lead and cadmium levels in frequently used cosmetic products in Iran. J Environ Public Health 2013; 25: 1-5.
  8. Ajayi OO, Oladipo MOA, Ogunsuyi HO, Adebayo AO. Determination of the minor and trace elements in birinwa tin pyrite and ornament lead/zinc ore using neuron activation analysis. Bull Chem Soc Ethiop 2002; 16(2): 207-211.
  9. Nduka JK, Odiba IO, Aghoghome EI, Umedum NL, Nwosu MJ. Evaluation of harmful substances and health risk assessment of mercury and arsenic in cosmetic brands in Nigeria. Int J Chem 2016; 8(1): 178-187.
  10. Ogunkunle CO, Fatoba PO, Ogunkunle MO, Oyedeji AA. Potential Health Risk Assessment for Soil Heavy Metal Contamination of Sagamu, South-west Nigeria due to Cement Production. Int J Appl Sci Technol 2013;3( 2): 89-96.
  11. Al-Dayel O, Hefne J, Al-Ajyan T. Human exposure to heavy metals from cosmetics. Orient J Chem 2011;27(1):1–11.
  12. Khalid A, Bukhari IH, Riaz M. Determination of lead, cadmium, chromium, and nickel in different brands of lipsticks. Int J Biol Pharm Allied Sci 2013; 1(2): 263–271.
  13. Orisakwe OE, Otaraku JO. Metal concentrations in cosmetics commonly used in Nigeria. Sci World J 2013; 14(1): 50–56.
  14. Mousavi Z, Ziarati P, Shariatdoost A. Determination and safety assessment of lead and cadmium in eye shadows purchased in local market in Tehran. J Environ Anal Toxicol 2013; 3(7):1-4
  15. Al-Saleh I, Al-Enazi S, Shinwari N. Assessment of lead in cosmetic products. Regul Toxicol Pharmacol 2009; 54(2): 105–113.
  16. Volpe MG, Nazzaro M, Coppola R, Rapuano F, Aquino RP. Determination and assessments of selected heavy metals in eye shadow cosmetics from China, Italy, and USA. Microchem J 2012; 101: 65–69.
  17. Sainio EL, Jolanki R, Hakala E, Kanerva L. Metals and arsenic in eye shadows. Contact Dermatitis 2000;42(1) :5-10
  18. Iwegbue CMA, Bassey FI, Obi G, Tesi GO, Martincigh BS. Concentrations and exposure risks of some metals in facial cosmetics in Nigeria. Toxicol Rep 2016; 3(8):464-472
  19. Hardy A, Wallton R, Vaishnav RJ. Composition of eye cosmetics (kohls) used in Cairo. Int J Environ Health Res 2004; 14(1):83-91.
  20. Hardy A, Wallton R, Myers KA, Vaishnav R. Availability and chemical composition of traditional eye cosmetics ("kohls") used in the United Arab Emirates of Dubai, Sharjah, Ajman, Umm Al-Quwain, Ras Al-Khaimah, and Fujairah. J Cosmet Sci 2006; 57(2):107-125.
  21. Al-Ashban RM, Aslam M, Shah AH. Kohl (surma): a toxic traditional eye cosmetic study in Saudi Arabia. Public Health 2004; 118(4):292-298.
  22. Lekouch N, Sedki A, Nejmeddine A, Gamon S. Lead and traditional Moroccan pharmacopoeia. Sci Total Environ 2001; 280(1-3):36-43.
  23. Iwegbue CMA, Emakunu OS, Nwajei GE, Bassey FI, Martincigh BS. Evaluation of human exposure to metals from some commonly used bathing soaps and shower gels in Nigeria. Regul Toxicol Pharmacol 2017; 83(4): 38-45
  24. World Health Organization. Environmental Health Criteria 165: Inorganic Lead, Geneva: International Programme on Chemical Safety. World Health Organization, Geneva. 133. 1995.
  25. Basketter DA, Angelini G, Ingber A, Kern PS, Menne T. Nickel, chromium and cobalt in consumer products: revisiting safe levels in the new millennium. Contact Dermatitis 2003; 49(1): 1–7.
  26. Basketter DA, Briatico-Vangosa G, Kaestner W, Lally C, Bontinck WJ. Nickel, cobalt and chromium in consumer products: a role in allergic contact dermatitis? Contact Dermatitis 1993; 28(1): 15–25.
  27. Allenby CF, Basketter DA. An arm immersion model of compromised skin. II. Influence on minimal eliciting patch test concentrations of nickel. Contact Dermatitis 1993; 28(3): 129–133.
  28. Abd El-Aziz R, Abbassy MMS, Hosny G. A comparative study on health risk Assessments of some heavy metals in cosmetics commonly used in Alexandria, Egypt. Int J Environ Sci Toxic Res 2017; 5(3): 53-62.
  29.  Liu X, Song Q, Tang Y, Li W, Xu J, Wu J, et al. Human health risk assessment of heavy metals in soil-vegetable system: a multi-medium analysis. Sci Total Environ 2013; 463-464:530-540.