Applicable risk assessment methods in occupational and environmental exposure to nanoparticles - a narrative review

Document Type : Review Article(s)

Authors

1 Department of occupational Health Engineering, Environmental health research center, Kurdistan University of Medical Sciences, Sanandaj, Iran

2 PhD. Students of Occupational Health, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

3 Department of Occupational Health, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

Abstract

Nanoparticles (NPs) are a heterogeneous group of materials that have various applications, and their risk assessment is an essential condition. This study aimed to review the applicable risk assessment methods in occupational and environmental exposures to NPs. A literature search for articles published since 2005 in Web of Knowledge, Scopus, PubMed, Science Direct, and Google Scholar, using appropriate keywords such as “Risk Assessment,” “Nanoparticle,” and “Nanomaterial,” revealed 56 articles, which were screened by two researchers. A total of 15 articles were reviewed in full text. In total, 11 applied techniques for NP risk assessment were analyzed. Seven methods were quantitative, and four were qualitative. The quantitative methods were Integrated Probabilistic Risk Assessment (IPRA), Integrated Probabilistic Environmental Risk Assessment (IPERA), Quantitative Structure-Activity QSTR-Perturbation Model, Lung Dosimetry Modeling for Quantitative Risk Assessment (LDMQRA), Physiologically Based Pharmacokinetic Modeling (PBPK), Risk assessment based on toxicokinetic modeling, and Risk assessment of NPs with Spray Application. The qualitative methods were Application of Toxicogenomics for Risk Assessment, Luminous Microbial Array for Toxicity Risk Assessment (Lumi MARA), Control Banding Nano Tool (CBNT), and Stoffenmanager Nano Tool. It can be concluded that each of the studied methods evaluates an NP and is specifically used for that NP. A general risk assessment approach cannot be applied to all NPs but should be separately investigated by different processes.

Keywords


  1. Shafiee Motlagh M, Aghaei H, Assari M J, Soltani Mohammadi Samar M. Design and providing of a software package based on Control Banding method for risk assessment of occupational exposure to nanomaterials. Iran occupational health journal2017;14(1):71-80.
  2. Assari Mj, Rezaee A, Rangkooy H. Bone char surface modification by nano-gold coating for elemental mercury vapor removal. Appl Surf Sci 2015:342(14):106–11.
  3. Assari Mj, Rezaee A, Jafari AJ, Bahrami A. Development of a novel setup for direct colorimetric visualization of elemental mercury vapor adsorption on colloidal gold nanoparticles. Iran J Health Saf Environ 2014;1(3):111-6.
  4. Jacobs R, Van Der Voet H, Ter Braak CJ F. Integrated probabilistic risk assessment for nanoparticles: the case of nanosilica in food. J Nanopart Res 2015;17(6):251.
  5. Jacobs R, Meesters JA, Ter Braak CJ, Van de Meent D, Van der Voet H. Combining exposure and effect modeling into an integrated probabilistic environmental risk assessment for nanoparticles. Environ Toxicol Chem 2016;35(12):2958-67.
  6. Jung Y, Park CB, Kim Y, Kim S, Pflugmacher S, Baik S. Application of Multi-Species Microbial Bioassay to Assess the Effects of Engineered Nanoparticles in the Aquatic Environment: Potential of a Luminous Microbial Array for Toxicity Risk Assessment (LumiMARA) on Testing for Surface-Coated Silver Nanoparticles. Int J Environ Res Public Health 2015;12(7):8172-86.
  7. Silva F, Arezes P, Swuste P. Risk assessment in a research laboratory during sol–gel synthesis of nano-TiO2. Saf Sci 2015;80:201–12.
  8. Pourhamzeh M, Gholami Mahmoudian Z, Saidijam M, Asari MJ, Alizadeh Z. The effect of silver nanoparticles on the biochemical parameters of liver function in serum, and the expression of caspase-3 in the liver tissues of male rats. Avicenna J Med Biochem 2016;4(2):1-5.
  9. Gholami Mahmoudian Z, Sohrabi M, Lahoutian H, Assari MJ, Alizadeh Z. Histological alterations and apoptosis in rat liver following silver nanoparticle intraorally administration. Entomol Appl Sci 2016;3(5):27-35.
  10. Saeidi Ch, Asari M, Ghorbani-Shahna F, Khamverdi Z. Removal of mercury vapor from ambient air of dental clinics using an air cleaning system based on silver nanoparticles. J Occup Hyg Eng 2015;2(1):1-10.
  11. Kroll A, Pillukat MH, Hahn D, Schnekenburger J. Current in vitro methods in nanoparticle risk assessment: Limitations and challenges. Eur J Pharm Biopharm 2009;72(2):370–77.
  12. Kuempel E D, Tran C L, Castranova V, Bailer A J. Lung Dosimetry and Risk Assessment of Nanoparticles: Evaluating and Extending Current Models in Rats and Humans. Inhal Toxicol 2006;18(10):717-24.
  13. Zalk D M, Paik S Y, Swuste P. Evaluating the Control Banding Nanotool: A qualitative risk assessment method for controlling nanoparticle exposures. J Nanopart Res 2009;11:1685-704.
  14. Kleandrova VV, Luan F, Gonzalez-Diaz H, Ruso JM, Speck-Planche A, Cordeiro MN.  Computational tool for risk assessment of nanomaterials: Novel QSTR perturbation model for simultaneous prediction of ecotoxicity and cytotoxicity of uncoated and coated nanoparticles under multiple experimental conditions. Environ Sci Technol 2014;48(24):14686–94.
  15. Labib S, Williams A, Yauk CL, Nikota JK, Wallin H, Vogel U, Halappanavar S. Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes. Part Fibre Toxicol  2016;15(13):1-17.
  16. Bachler G, Von Goetz N, Hungerbuhler K. Using physiologically based pharmacokinetic (PBPK) modeling for dietary risk assessment of titanium dioxide (TiO2) nanoparticles. Nanotoxicology 2015;9(3):373-80.
  17. Van Kesteren PC, Cubadda F, Bouwmeester H, van Eijkeren JC, Dekkers S, De Jong WH, et al. Novel insights into the risk assessment of the nanomaterial synthetic amorphous silica, additive E551, in food. Nanotoxicology 2015;9(4):442-52.
  18. Heringa MB, Geraets L, Van Eijkeren JC, Vandebriel RJ, De Jong WH, Oomen AG. Risk assessment of titanium dioxide nanoparticles via oral exposure, including toxicokinetic considerations. Nanotoxicology 2016;10(10):1515-25.
  19. Bakand S, Hayes A. Toxicological Considerations, Toxicity Assessment, and Risk Management of Inhaled Nanoparticles. Int J Mol Sci 2016;17(6):929.
  20. Michel K, Scheel J, Karsten S, Stelter N, Wind T. Risk assessment of amorphous silicon dioxide nanoparticles in a glass cleaner formulation. Nanotoxicology 2013;7(5):974–88.